AB1282 OVARIAN RESERVE IN BEHCET’S DISEASE

Background Behcet’s disease (BD) is a multisystemic of unknown cause. Anti-Mullerian hormone (AMH) one the key parameters for assessing reproductive function and ovarian reserve. The levels AMH correlates with residual follicular pool in women age. Objectives To assess BD female patients child-bearing potential, analyze relationship between severity, as well serum different therapeutic regimens. Methods study group included 45 (according to ISGBD 1990 ICBD 2014) aged 20-40 years, control icluded 15 age-matching healthy women. Pts’ mean age was 31,3 [27;35] yrs, duration 6 [3;8] yrs. 17,8% pts had severe according Ch.Zouboulis classification (due generalized uveitis, retinal vasculitis parenchymatous CNS lesions), 37,8% moderate disease, 44,4% mild mainly dermal-mucous manifestations. measured using ELISA. reference values ranged within 1.0-10.6 ng / ml. Values <1.0 were interpreted decreased Results 2.5 ng/ml pts, 3.1 group, showing no statistical difference. A decrease reserve (AMH less than 1.0 ng/ml) observed same frequency 18% patient’s vs. 13%. In analysis AMH, depending on severity BD, more often forms BD. Table 1. mild, n=20 n=17 severe, n= 8 p АMH 2,7 [1,6-3,5] 2,5 [1,0-3,7] 1,9 [0,8;6,7] ns >1 ng/ml, % 10 23 25 0,02 There are correlations treatment noted two under 30 years old, 29 old woman “Neurobehcet” children, patient BB+AS not married, pregnancies, received colchicine therapy long time. Two low pregnancies - unmarried, all other reduced from 1 children. When analyzing clinical picture therapy, found. Conclusion average did differ. occurred controls. References [1]Zouboulis C., Vaiopoulos G., Macromichelakis N. et al. Onset signs, course, prognosis, outcome adult Adamantiades – Greece. Clin.Exp.Rheum.2003, 21, (suppl.30) S19-S26. Disclosure Interests None declared